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KMID : 1100220050040020059
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Dementia and Neurocognitive Disorders
2005 Volume.4 No. 2 p.59 ~ p.62
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Promising Treatment of Alzheimer’s Disease
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Eah Kyung-Yoon
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Abstract
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Alzheimer’s disease (AD) is one of the most important health problems in aging society and around the world. Five drugs have now been approved for the treatment. First four drugs of these are cholinesterase inhibitors and the latest one is an antagonist of the NMDA glutamate receptor. The former indicated for the treatment of mild to moderate AD, the latter is useful in treating of moderate to severe stage. But the benefits of above are mainly symptomatic. Disease modifying therapy is the main target of therapeutic research on AD now. The hallmarkers of AD pathology are the amyloid plaque and the neurofibrillary tangles. Based on the amyloid hypothesis, the anti-amyloid treatment and anti-polymerization starategies are in process of development of the new disease-modifying agent. These drugs reduce the level of Aβ42 or its toxicity and protect brain cells against Aβ damage. The other treatment that stabilize the microtuble is under investigation. It appears likely that another major advances in AD therapy are on the near horizon.
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KEYWORD
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Alzheimer’s disease (AD), Cholinesterase inhibitor, NMDA-glutamate receptor agonist, Amyloid, Microtuble
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